| ORIGINAL ARTICLE |
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| Year : 2013 | Volume
: 31
| Issue : 4 | Page : 249-253 |
Vitapex can promote the expression of BMP-2 during the bone regeneration of periapical lesions in rats
Xianyin Xia1, Zhaozhao Man1, Hui Jin1, Ruirui Du1, Wenjing Sun2, Xiumei Wang1
1 Department of Dentistry, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
2 Laboratory of Medical Genetaics, Harbin Medical University, Harbin, China
Correspondence Address:
Xiumei Wang
Department of Dentistry, the Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Nangang District, Harbin 150086
China
 Source of Support: This work was supported by Natural
Science Foundation of Heilongjiang Province of China
(D201175), and Postdoctoral Science Foundation of
Heilongjiang Province (LRB05-279) (to X.W.),, Conflict of Interest: None  | Check |
DOI: 10.4103/0970-4388.121825
Purpose: To investigate the effect of Vitapex on the healing of periapical lesions and the expression of bone morphogenetic protein (BMP-2) during the periapical bone regeneration. Materials and Methods: Periapical lesions were induced in Sprague-Dawley (S-D) rats by an occlusal pulp exposure in the mandibular first molars and were verified by X-ray. Total of 36 rats were randomly divided into three groups, and they were obturated with Zinc Oxide Eugenol (ZOE), or with Vitapex, or non-treated as negative control group. The rats of three groups were randomly killed at week 0, 2, 4, and 8 after root canal therapy, and then the mandibles were processed for histological examination and immunohistochemistry analysis. Results: At week 0, only a few BMP-2 positive cells could be observed in all rats. While the expression of BMP-2 was dramatically increased in case of Vitapex group at week 2 and week 4, and then climaxed at week 8. However, no apparent changes were observed in ZOE group and negative group at week 2, 4, and 8. Conclusion: These observations suggested that Vitapex has a greater ability in inducing bone regeneration than ZOE by the expression of BMP-2 induction in the treatment of rats experimental periapical lesions.
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