| CASE REPORT |
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| Year : 2009 | Volume
: 27
| Issue : 4 | Page : 249-252 |
Cleidocranial dysplasia: A family report
H Thamizh Chelvan1, N Malathi1, Vignesh Kailasam1, A Ponnudurai2
1 Departments of Oral Pathology, and Orthodontia, Sri Ramachandra DentalCollege, Porur, Chennai, India
2 Department of Paedodontia, Sri Ramachandra DentalCollege, Porur, Chennai, India
Correspondence Address:
H Thamizh Chelvan
Department of Oral Pathology, Sri Ramachandra Dental College and Hospital, Sri Ramachandra University, Porur, Chennai - 600 116
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0970-4388.57661
A 10-year-old girl presented with a chief complaint of many unerupted teeth. Complete clinical and radiological examination of this patient confirmed the diagnosis of cleidocranial dysplasia (CCD). Her father also presented similar features with a lesser clinical severity. CCD is an autosomal-dominant heritable skeletal disease caused by heterozygous mutations in the osteoblast-specific transcription factor RUNX2 gene. Failure of tooth eruption is probably mainly due to this mutated gene in CCD patients. Interdisciplinary treatment approach is obligatory for rehabilitation of these patients. In confirmed cases, genetic counseling for family planning should certainly be advised.
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