| ORIGINAL ARTICLE |
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| Year : 2009 | Volume
: 27
| Issue : 3 | Page : 135-138 |
Natural prevalence of antibody titres to GTF of S. mutans in saliva in high and low caries active children
BC Kirtaniya1, HS Chawla2, A Tiwari3, NK Ganguly4, V Sachdev1
1 Department of Pedodontics, Himachal Dental College, Sunder Nagar, H.P, India
2 Oral Health Science Centre, PGIMER, Chandigarh, India
3 Oral Health Science Centre, Dean, PGIMER, Chandigarh, India
4 Former Director General ICMR (New Delhi), India
Correspondence Address:
B C Kirtaniya
Himachal Dental College Sundernagar
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0970-4388.57092
The present study was conducted to find out the role of natural immunity against dental caries. Whole stimulated saliva of various caries active children was collected. Antigen glucosyltransferase (GTF) was prepared from Streptococcus mutans serotype c and the antibody titre was estimated using ELISA. Salivary IgG, s-IgA and total immunoglobulins (IgG + s-IgA+ IgM) concentration were assayed. The result showed an increased level of salivary IgG concentration with the increased number of dental caries, which was not statistically significant. But there were significant decrease of s-IgA titre as well as total immunoglobulin concentration in saliva with the increased number of dental caries. This study showed that because of lack of local immunity the children are more prone to dental caries.
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